It's a given that Clayton Kershaw won't get much run support each time he pitches. Entering Wednesday's game against the San Diego Padres, the Dodgers scored an average of 2.62 runs per game with their ace on the mound, fewer than all but three major-league starters.

Forget about runs. Kershaw would've taken a hit Wednesday.

The left-hander pitched well enough to win most nights, but the Dodgers were no-hit by Padres starter Jason Marquis (7-2) until Kershaw (5-4) was pulled from the game in the sixth inning. San Diego went on to win 6-2 in front of an announced crowd of 40,004 at Dodger Stadium.

The Dodgers were denied the series sweep, the chance to match their longest winning streak of the season and the chance to move out of fifth place in the National League West for the first time since May 4.

The Padres scored an unearned run in the second inning, then tacked on single runs in the fourth and sixth against Kershaw to take a 3-0 lead.

Rookie sensation Yasiel Puig went quietly in his three at-bats against Marquis. He grounded out twice then struck out for the first time in his career in the sixth inning. He struck out looking in the eighth inning against Dale Thayer to finish 0 for 4, lowering his batting average to .417.

Puig wasn't alone in his misery.

Marquis, 34, teased the Dodgers hitters for six innings and teased Padres fans with the possibility of the first no-hitter in franchise history.

The right-hander was an unlikely hero. He brought a 6-2 record into the game but had lasted only 83 innings in his previous two starts combined.

Marquis had five shutouts in 301 career starts.

The Dodgers didn't get a baserunner until Andre Ethier walked in the fifth inning. Jerry Hairston Jr. nearly broke up the no-hitter when he hit a sinking line drive to right field as a pinch hitter in the sixth inning but was robbed by Kyle Blanks' diving catch.