Major League Baseball, which has been investigating the link of performance-enhancing drugs to players with South Florida ties for much of the last year, may be faced with its most significant doping case since the BALCO scandal rocked the sport one decade ago.

All-Stars Alex Rodriguez of the New York Yankees, pitcher Gio Gonzalez of the Washington Nationals, Nelson Cruz of the Texas Rangers and Melky Cabrera of the Toronto Blue Jays, along with other MLB players and athletes in other sports, were strongly connected to performance-enhancing drug use in an investigative report by the Miami New Times.

The report revealed records from Biogenesis, a South Florida clinic, that indicated players received illegal substances from Anthony Bosch, the head of the clinic, who is already under investigation by the Drug Enforcement Agency.