Their rivalry has often featured heavyweights throwing haymakers, but Friday’s game will be nothing more than a slap fight.

The fourth and final regular-season matchup between the Celtics and Heat, teams that loathe each other to the core, may be without most of the players who often make their games worth watching.

The Celtics brought their horses to South Beach, but are keeping Kevin Garnett and Paul Pierce in the stable because of sore ankles, the team announced Thursday. They have been more apt to rest their 35-and-older star duo as the playoffs near.

Garnett recently missed eight games and Pierce missed two. The Celtics are 0-3 without Pierce this season and 5-6 without Garnett.

As for the Heat, LeBron James, Dwyane Wade, and Chris Bosh (as well as Udonis Haslem) sat out Wednesday’s win over the Wizards to rest, and it’s unclear if any will play against Boston, although Wade told the Associated Press he plans to return after missing six games with knee soreness.

The Heat have locked up the No. 1 seed in the Eastern Conference and home-court advantage throughout the playoffs, and is in cruise control.

“It’ll be an interesting game, because who knows who they’ll play?” Celtics coach Doc Rivers said after his team’s 101-93 loss to the Nets Wednesday night at TD Garden.