Three years ago, almost to the day, Dustin Pedroia became an enemy of the state of Colorado.

Not literally, mind you. But on June 24, 2010, he went 5-for-5 with three home runs and four RBI for the Red Sox in the finale of a series at Coors Field, then punctuated his definitive “laser show” by cracking, “I’m wanted for murder in Colorado!”

Since then, thanks to the irregularity of interleague play, Pedroia has been able to vanish like Edward Snowden from the Rockies’ sight. Until tonight, that is, when the Rox made a rare visit to Fenway Park, and once again, bore the brunt of the second baseman’s offensive might.

In the first three innings, Pedroia came to the plate three times, each with at least one runner on base, against Rockies starter Juan Nicasio. And each time, he delivered a hit and drove in a run en route to a three-hit, four-RBI night that propelled an 11-4 rout in the opener of a two-game series.

If Pedroia’s power display at Coors was akin to murder, what, then, was this?

To be fair, Pedroia wasn’t alone in rocking the Rockies. Hardly. The Red Sox pounded out a season-high 20 hits, three apiece by Jacoby Ellsbury, Pedroia, slumping Daniel Nava and scorching Jose Iglesias. They scored two runs in the first inning, three in the second and two in the third, allowing starter Ryan Dempster to pitch on cruise control for six innings and giving their in-flux bullpen a big cushion.

But Pedroia was the pace-setter. His one-out single in the first inning scored Ellsbury with the first run. The lead was only 2-0 in the second inning when Pedroia’s double to right field drove in Shane Victorino.

And with the margin having swelled to 6-1 in the third, Pedroia laced another one-out RBI single and knocked out Nicasio in favor of Northeastern product Adam Ottavino. For good measure, he showed off his vertical leap on a catch of DJ LeMahieu’s liner in the third inning.

Surely, the Sox needed a laugher. After dropping 3-of-4 games in Detroit and 7-of-11 overall, their lead had been cut to 21⁄2 games in the AL East, where the standings resemble a traffic jam at rush hour.

Turns out, the Rockies may be a good elixir.

At the tail end of a nine-game road trip that included five consecutive losses to the Blue Jays and Nationals, they were hammered over the first four innings. The Sox sent eight batters to the plate in a first that may have been far more damaging except that Jarrod Saltalamacchia struck out and Stephen Drew fouled out with the bases loaded and two runs already in.