David Ortiz is at it again.

The Red Sox designated hitter almost single-handedly carried his team to an 12-5 win over the Twins Saturday night at Target Field, with Ortiz claiming the 40th multi-home run game of his career via a pair of blasts. It marked the fourth time in Ortiz’ career he has claimed six RBIs, having last accomplished the feat Aug. 12, 2008.

In the 21 games he has notched at least one hit (out of 24), Ortiz is hitting .420, and is 9-for-19 on the current road trip. At Target Field, the DH is hitting .500 (19-for-38) with five home runs.

Also helping the Sox’ offensive onslaught was Daniel Nava, whose seventh-inning, two-run helped cap a game-changing four-run frame for the Sox. The outfielder joined Will Middlebrooks, Dustin Pedroia and Ortiz as members of the Red Sox claim multi-hit games.

The were moments of discomfort for the Red Sox, especially in the fifth inning when Ryan Dempster couldn’t manage to get the final out of the frame before being removed for Clayton Mortensen. Red Sox manager John Farrell left the starter in for 127 pitches (the second-most he had thrown since 2001), having had to watch the Twins bring the potential go-ahead run to the plate.