The owner of the South Florida anti-aging clinic at the center of baseball’s latest doping scandal asked embattled Yankee star Alex Rodriguez for financial help after Major League Baseball filed a lawsuit that alleged he had sold performance-enhancing drugs to Major League Baseball players.

When Rodriguez rebuffed Anthony Bosch’s request for money, believed to be in the hundreds of thousands, the self-styled “biochemist” turned to a strange bedfellow — MLB.

“A-Rod refused to pay him what he wanted,” said a source. “Baseball was worried about that.”

MLB reached an agreement this week for Bosch’s cooperation in its long-running investigation into one of the biggest drug scandals in baseball history and plans to meet with him on Friday.

The Daily News reported Wednesday that baseball was concerned Bosch might turn to players for financial help if MLB didn’t lock him into an agreement to testify.

“They were afraid someone else would pay him,” said the source. “Bosch is the only guy that can provide them with what they need.”

Bosch is expected to provide MLB with enough dirt to suspend Rodriguez and nearly two dozen other players, sources familiar with the Biogenesis case have told The News, including Milwaukee Brewers outfielder Ryan Braun, who has had a target on his back since he successfully appealed a positive drug test last year.

According to one source familiar with the investigation, Bosch and his lawyer, Susy Ribero-Ayala, told MLB that Bosch will provide them with damaging information about his past dealings with A-Rod and Braun, including that he “treated” the Brewers slugger when the player was a student at the University of Miami.

“Due to ongoing litigation, it would be inappropriate to comment on any aspect of this matter at this time,” Ribero-Ayala, said in a statement released on Wednesday.